Tramvetol 50 mg

For the reduction of acute and chronic mild soft tissue and musculoskeletal pain.

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Tramvetol 50 mg tablets provide a potent, dual-action analgesic solution for dogs. Designed for rapid absorption and proven efficacy, it offers a reliable and well-tolerated option for managing acute and chronic mild soft tissue and musculoskeletal pain, helping to restore your patients' quality of life.

  • Dual mechanism of action non-selective agonist of the mu-opioid receptor and inhibitor of norepinephrine and serotonin reuptake.
  • Rapid onset of action Tramadol is readily absorbed, and peak plasma concentrations are achieved within 45 minutes, making it a very useful tool for pain management.¹ ²
  • Proven efficacy High analgesic efficiency demonstrated in veterinary clinical studies and confirmed by its wide use in human medicine.¹
  • Meat-flavoured tablets To increase palatability and patient acceptance.
  • Easily divisible 50 mg tablets for accurate and flexible dosing.
  • Safety Effective and rapid analgesic action with a well known tolerance profile, suitable for both short treatment courses and long-term management³. Unlike most common opioids, side effects like reduction of intestinal movements, bradycardia and respiratory depression are not expected.
  • Combinable Tramadol is trusted to be used in combination with NSAIDs, possibly reducing the overall cost of treatment and risk of side effects.⁴

Available in Great Britain.

Technical support

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Presentation

White to almost white, flat tablets with rounded edges, brown dots, and a break line on one side. The tablets feature a characteristic meat smell and can be divided into two equal parts. Packaged in white PVC/PE/PVDC-aluminium blisters. Available in boxes of 3 blisters of 10 tablets or 10 blisters of 10 tablets.

Indications

For the reduction of acute and chronic mild soft tissue and musculoskeletal pain in dogs weighing more than 6.25 kg.

Clinical characteristics & efficacy

Tramvetol features tramadol, a centrally acting analgesic with a complex dual mechanism of action. It acts as a non-selective agonist of the mu-opioid receptor (MOR) and inhibits the neuronal reuptake of norepinephrine and serotonin. Tramadol is readily absorbed following oral administration, reaching peak plasma concentrations within 45 minutes, making it highly effective for rapid pain management.²

Unlike most common opioids, tramadol does not typically induce side effects such as respiratory depression, bradycardia, or reduced gastrointestinal motility across an extensive analgesic dose range. It is metabolised in the liver to its primary active metabolite, O-desmethyltramadol,² and offers a proven safety and efficacy profile widely recognised in veterinary medicine.³

Active ingredient

Tramadol (as hydrochloride)

Dosage & administration

For oral use in dogs weighing more than 6.25 kg.

  • Recommended dose: 2-4 mg tramadol hydrochloride per kg body weight every 8 hours, or as needed based on the intensity of pain.
  • Minimum dosing interval: 6 hours.
  • Recommended maximum daily dose: 16 mg/kg.

As individual response to tramadol is variable, the optimal dosing regimen should be individually tailored based on dosage, patient age, pain sensitivity, and general condition. Tablets can be divided into two equal parts to ensure accurate dosing. For chronic pain, multimodal analgesia (e.g., combining with NSAIDs) should be considered.⁴

Safety, precautions & storage

Special Precautions

  • Use with caution in dogs with renal or hepatic impairment; dosing regimens may need adjustment.
  • Mild sedation and drowsiness may commonly occur, especially at higher doses. Nausea and vomiting are uncommonly observed.
  • The analgesic effect may be variable due to individual differences in metabolism (non-responders).²
  • Use during pregnancy or lactation only according to a benefit-risk assessment by the responsible veterinarian.

Storage

  • This veterinary medicinal product does not require any special storage conditions.
  • Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
  • Shelf life of divided tablets: 3 days.
  • Keep out of the sight and reach of children. Return unused tablet parts to the open blister space and insert back into the carton.

References

1. Cepeda MS et al. Tramadol para la osteoartritis. Biblioteca Cochrane Plus 3, 2008.

2. KuKanich B, Papich MG. Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. J Vet Pharmacol Ther. 2004 Ago; 27(4):239-46.

3. Animal safety studies on u26, 225A. One-year oral toxicity study in the dog ND5087/PR4-6A/100. Data on file.

4. World Health Organization. Cancer pain relief. Albany, NY: WHO Publication Center; 1986.

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