Virbac UK Veterinary

Oxidative Stress : Its Impact on Transition Cows

The trace mineral levels in cattle are not static; they change throughout the production cycle depending on the demands on the animal.

large animal graph 6.PNGSwenson 19981 showed the natural decline in trace mineral status of cows in the last trimester of pregnancy, as there is an increasing demand for trace minerals for foetal development, see Fig 1.

Cows having adequate liver Cu stores pre-calving (110 ppm) became marginally deficient by the time of parturition (80 ppm). Even in well fed (orally supplemented) cows, oxidative stress occurs due to depressed oral feed intake prior to and following calving, or during periods of stress.

large animal graph 7.PNG

During the transition period, the energy requirement that is needed for foetal growth and milk synthesis increases dramatically, exceeding the amount of energy the cow can obtain from dietary sources (negative energy balance), see Fig 2.

Fatty acid oxidation in the liver, results in the increased production of free radicals and oxidative stress development 2 .

Free radical generation increases as metabolic rate increases and the need for antioxidant enzymes to metabolize free radicals increases 3. (Refer to the article on oxidative stress, its effect on cattle and the role of trace minerals).

Production of oxidizing agents has been suggested to occur in many disease problems of cattle such as: milk fever, mastitis and retained placenta; the antioxidant system becomes impaired with acceleration in the process of lipid peroxidation 4 .

Piccinini et al (2004)5 showed the significant oxidative stress, that the period immediately prior to and following parturition imposes on the first calf heifer. In their first lactation heifers are recovering from their first calving, commencing lactation, trying to conceive once again and all this while they are still growing. This study also showed significant decreases in Superoxide Dismutase during the period of 14 days following parturition, compounding oxidative stress.

In a Cornell University study, dairy cows given an injectable trace mineral supplement 60 days pre-calving, 30 days pre-calving and 35 days in milk showed health throughout lactation 6. Cattle supplemented this way also showed raised levels of the key antioxidant enzyme Superoxide Dismutase through the transition period to100 days in milk7 , this could mitigate the potential role of oxidative stress in the transition period.major improvements in overall herd.

1. Swenson, C.K. 1998. Influence of mineral supplementation on blood serum and liver mineral concentrations in first calf beef heifers. Ph.D. Dissertation. NM State Univ., Las Cruces.
2. Miller J.K. et al 1993. Oxidative Stress, Antioxidants and Animal Function 1993 J Dairy Sci 76:2812-282
3. Underwood & Suttle, 1999. The Mineral Nutrition of Livestock
4. Al-Qudah K.M. 2009. Oxidative Stress in Calves with Acute or Chronic Bronchopneumonia Revue Méd. Vét., 2009, 160, 5, 231-236
5. Piccinini R. et al. 2004. The evaluation of non-specific immune status of heifers in field conditions during the periparturient period 539 Vet. Res. 35 (2004) 539–550
6. Machado V.S. Bichalo M.L.S., Pereira, R.V., Caixeta L.S., Knauer W.A., Oikonomou. G, Gilbert R.O., Bichalo, R.C., 2013. Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on the health and production of lactating Holstein cows
7. Machado V.S., Oikonomou G, Lima S F, Bichalo M.L.S., Kacar C., Foditsch C., Felippe MJ, Gilbert R.O. Bichalo R.C., 2014, The effect of injectable trace minerals on peripheral blood leukocyte activity and serum superoxide dismutase.