Introducing Cortotic, a Revolutionary Treatment for Canine Otitis Externa – Without an Antimicrobial!
The World Health Organization has declared that antimicrobial resistance is one of the top global public health threats of our time3. A coordinated, collaborative approach in the UK has led to a reduction in veterinary antibiotic use, but there is still more that we can do. Otitis externa is the most frequently recorded disorder seen in primary care veterinary practice, with a reported prevalence of 10.2%4, and is therefore an area of significant potential to decrease antimicrobial use.
Cortotic contains Hydrocortisone Aceponate (HCA) and treats the clinical signs associated with acute erythroceruminous otitis externa1 (ECOE), even where microbial overgrowth is present2, by addressing the primary factor – inflammation.
In a clinical field study, published in Veterinary Dermatology, Cortotic was shown to be as effective in treating acute otitis as a fixed-combination product containing a corticosteroid, an antibiotic and an antifungal as active ingredients, with an equivalent improvement of clinical and cytological scores5. A secondary reduction of bacterial and yeast overgrowth was demonstrated and a concomitant treatment with an antimicrobial was unnecessary. The product was shown to provide rapid relief from clinical signs, pruritus and pain5.
Hydrocortisone Aceponate (HCA) is a potent unique diester glucocorticosteroid which provides rapid relief of inflammation. The lipophilic nature of the HCA diester provides enhanced penetration into the skin, a reservoir effect and low plasma availability for high local activity with reduced systemic secondary effects6.
With Cortotic we’re excited to offer clinicians the ability to reduce antimicrobial usage when treating otitis externa in dogs, whilst offering the same efficacy as a fixed-combination product’ said Chris Newark, Product Manager at Virbac. ‘The product’s easy administration also makes it an attractive choice for pet owners with 94% of owners stating that they would choose to use Cortotic again7’.
Cortotic is presented in an easy to use gentle ear spray device with atraumatic cannula, which delivers a fine mist spray for even application. Dosing is simple and straightforward for pet owners - 2 pumps per application, whatever the dog’s size, just once per day for 7-14 days.
References:
1. For the treatment of clinical signs associated with acute erythroceruminous otitis externa (Cortotic Summary of Product Characteristics).
2. A secondary reduction of bacterial and yeast overgrowth was demonstrated and a concomitant treatment with an antimicrobial was unnecessary (Cortotic Summary of Product Characteristics).
3. World Health Organization. Antimicrobial resistance. 2023. https://www.who.int/newsroom/factsheets/detail/antimicrobial-resistance (accessed 9th April 2024).
4. O′Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC (2014) Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England. PLoS ONE 9(3): e90501.
5. Rigaut D, Briantais P, Jasmin P, Bidaud A. Efficacy and safety of a hydrocortisone aceponate containing ear spray solution in dogs with erythemato-ceruminous otitis externa: A randomised, multicentric, single-blinded, controlled trial. Vet Dermatol. 2024 Apr;35(2):197-206. 6. Cortavance Summary of Product Characteristics (SPC).
7. Pet-owners satisfaction of use questionnaire after the clinical field efficacy study.